Chrysin supplement benefit, 500 mg
Aromatase inhibitor, dose and dosage, extract, review and side effects
Influence on cancer, inflammation, testosterone levels, estrogen, thyroid gland, breast cancer
Is it helpful to those who lift weights or are involved in body building, for hair growth?
Combining with piperine, indole 3 carbinol, Bioperine
February 1 2017

Where is it found?
The flavonoid chrysin, a type of flavone, is found in many plants, in food, propolis, and is available as an herbal dietary supplement without a prescription. It is chemically extracted from the blue passion flower (Passiflora caerulea). It is also reported in Oroxylum indicum or Indian trumpetflower. Honeycomb also contains small amounts.

Health benefit of this chrysin supplement, why take it?
Claims are made that chrysin supplements are helpful for bodybuilding because it is an aromatase inhibitor. However, there does not appear to be much of a benefit for bodybuilders to take chrysin supplements. There is potential that this flavonoid could be an anti-cancer agent.Flavonoids have numerous health benefits including for heart health, as an anti-inflammatory to reduce inflammation, improving blood flow, and as anti-tumor agents.

Chrysin supplement availability, where to buy
There are a number of supplement companies that sell chrysin pills.

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Dosage: 500 mg to 2,000 mg daily as needed.

Chrysin 500 mg, 30 capsules

You can Buy Chrysin 500 mg supplement dietary supplement from a reliable online store

Chrysin (5,7-Dihydroxyflavone) 500 mg each pill

 

Chrysin, hormone, and testosterone influence, role of honey and propolis, it is an aromatase inhibitor?
Effects of chrysin on urinary testosterone levels in human males.
J Med Food. 2003. Gambelunghe C, Rossi R, Sommavilla M, Ferranti C, Rossi R, Gizzi S, Micheletti A. Department of Clinical and Experimental Medicine, Division of Sports Medicine-Laboratorio delle AttivitĂ  Motorie e Sportive, University of Perugia, Perugia, Italy.
The equilibrium of sexual hormones in both sexes is controlled in vertebrates by the enzyme aromatase, a member of the cytochrome P450 superfamily, which catalyzes the conversion of androstenedione and testosterone into estrone and estradiol, respectively. Flavonoids  present in whole grains, legumes, fruits, and vegetables are strongly implicated as protective in coronary heart disease, stroke, and cancer. One flavonoid, chrysin, found in high concentrations in honey and propolis, has been shown to be an inhibitor of aromatase enzyme activity. These foods are often used as supplements, particularly by sportsmen for their energetic and antioxidant properties. The aim of this study was to verify if daily treatment for 21 days with propolis and honey, containing chrysin, would modify urinary concentrations of testosterone in volunteer male subjects. In fact, aromatase inhibition by chrysin could block the conversion of androgens into estrogens with a consequent increase of testosterone. The obtained data did not show alterations of the levels of testosterone in the volunteers after treatment. In conclusion, the use of these foods for 21 days at the doses usually taken as oral supplementation does not have effects on the equilibrium of testosterone in human males.
Comments: Perhaps results may vary if chrysin supplements are used rather than honey or propolis, but we need more studies.

Chrysin, a natural flavonoid enhances steroidogenesis and steroidogenic acute regulatory protein gene expression in mouse Leydig cells.
J Endocrinol. 2008; Jana K, Yin X, Schiffer RB, Pandey AK, Grammas P. Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.
During the aging process of males, testosterone biosynthesis declines in testicular Leydig cells resulting in decreases in various physiological functions. To explore the possibility of delaying the decline using food supplements, we have studied steroidogenic effects of a natural flavonoid, chrysin, in mouse Leydig cells. Chrysin dramatically increased cyclic AMP induced steroidogenesis in Leydig tumor cells. The steroidogenic effect of chrysin is not associated with an increase in expression of the P450 side-chain cleavage enzyme, required for the conversion of cholesterol to pregnenolone. The majority of the observed increase in steroidogenesis was due to the increased supply of substrate cholesterol. Our results suggest that while chrysin itself is unable to induce StAR gene expression and steroidogenesis, it appears to function by increasing the sensitivity of Leydig cells to cAMP stimulation.

Brain health protection
Protective effects of Chinese propolis and its component, chrysin, against neuronal cell death via inhibition of mitochondrial apoptosis pathway in SH-SY5Y cells.
J Agric Food Chem. 2008; Izuta H, Shimazawa M, Tazawa S, Mishima S, Hara H. Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, Japan.
Endoplasmic reticulum stress has been implicated in the cause of neurons degenerating and ischemic disorders. The purpose of this study was to evaluate the effects of Chinese propolis and its constituents chrysin, galangin, pinocembrin, caffeic acid, and caffeic acid against tunicamycin-induced neuronal cell death. Both Chinese propolis and chrysin concentration-dependently inhibited such cell death. These findings indicate that the inhibitory effects of Chinese propolis against neuronal cell death induced by ER stress or staurosporine may be exerted primarily by chrysin. Moreover, the mechanism underlying the protective effects may, at least partly, involve inhibitions of caspase-3 activity and the mitochondrial apoptotic pathway.

Cancer
Chrysin inhibits expression of hypoxia-inducible factor-1alpha through reducing hypoxia-inducible factor-1alpha stability and inhibiting its protein synthesis.
Mol Cancer Ther. 2007; The Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Chrysin is a natural flavonoid and has been shown recently to have anticancer effects. However, the mechanisms that chrysin inhibits cancers are not well known. In this study, we investigated the effects of chrysin on expression of hypoxia-inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor in human prostate cancer DU145 cells. Chrysin inhibited insulin-induced expression of HIF-1alpha by reducing its stability. Chrysin increases ubiquitination and degradation of HIF-1alpha by increasing its prolyl hydroxylation. Results suggest that chrysin is a potent inhibitor of HIF-1alpha and provide a new sight into the mechanisms against cancers.

Inflammatory bowel disease
Chrysin, a natural flavone, improves murine inflammatory bowel diseases.
Biochem Biophys Res Commun. 2009. Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University, Chuncheon, GangwonDo, Republic of Korea.
In this study, we investigated whether chrysin could alleviate the symptoms of colitis in mice and whether chrysin has an inhibitory effect on nuclear factor (NF)-kappaB activation in vitro. Our findings suggest that chrysin exerts potentially clinically useful anti-inflammatory effects mediated through the suppression of NF-kappaB activation.

Leukemia protection
Chrysin inhibited stem cell factor complex-induced cell proliferation in human myeloid leukemia cells.
Biochem Pharmacol. 2007; Pharmaceutical Screening Team, Medicinal Science Division, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.
Stem cell factor (SCF) has important roles in the proliferation and differentiation of hematopoietic stem cells. Chrysin shuts down the SCF induced signaling cascade.

Liver protection
Effect of chrysin on hepatoprotective and antioxidant status in d-galactosamine-induced hepatitis in rats.
Eur J Pharmacol. 2010. Pushpavalli G, Kalaiarasi P, Veeramani C. Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamilnadu, India.
Chrysin is a natural, biologically active compound present in many plants and possesses potent anti-inflammatory, anticancer and antioxidation properties. This work was designed to investigate the effect of chrysin, on the liver protective efficacy in d-galactosamine-intoxication rats. d-galactosamine-induced toxicity was manifested by the elevation of serum hepatic marker enzyme activities (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and gamma-glutamyl transpeptidase) and the lipid peroxidation process and by decreasing the antioxidant capacity of the plasma, erythrocyte and tissues. Treatment with chrysin decreased hepatic marker enzyme activities and lipid peroxidation products such as thiobarbituric acid reactive substances, lipid hydroperoxides, increased the activities of free-radical scavenging enzymes superoxide dismutase, catalase and glutathione peroxidase and the levels of non-enzymatic antioxidants reduced glutathione, vitamin C and vitamin E. These findings demonstrate that chrysin acts as a liver protection benefits and antioxidant agent against d-galactosamine-induced liver toxicity.

Inquiries by readers
Is it true that the use of chrysin maximizes lean body composition?
We have seen no human studies that confirm this claim that it improves lean body composition.